Springfield is Jacksonville's oldest neighborhood and home of the Institute. The entire square mile of Springfield is on the National Historic Register. Mostly restored, preserved and renovated, The Historic District runs roughly from 1st Street (Downtown) to 12th Street, and nine blocks east from N. Jefferson Street. The University of Florida Medical School, UF Health Jacksonville, UF Health Proton Therapy Institute, the VA Clinic and Public Health Department sit on a large medical campus in Springfield's northwest corner.

Most Springfield rentals are within a mile of the Institute and just a mile or so to downtown restaurants and entertainment, the river, the gym, the sports complex, the main library, etc, which make it a good place to live for many of our staff. Reasonable rental rates reflect the neighborhood's residual rough edges and the genuine kindness toward our patients by local residents.